2020

FKBPL-based peptide, ALM201 targets angiogenesis and cancer stem cells in Ovarian cancer

[Journal Article] Annett S, Moore, G, Short A, Marshall A, McCrudden C, Yakkundi A, Das S, McCluggage G, Harley I, Moustafa N, Kennedy C, DeFazio A, Brand A, Sharma R, Brennan DJ, O’Toole S, O’Leary J, Wappett M, Cotton G, Harrison T, O’Connor DP, Furlong F, McCarthy H, Kissenpfennig A, McClements L & Robson T. | British journal of Cancer (IF:3.288) | Published February, 2020

2019

Targeted DNA Methylation Profiling of Human Cardiac Tissue Reveals Novel Epigenetic Traits and Gene Deregulation Across Different Heart Failure Patient Subtypes

[Journal Article] Glezeva N, Moran B, Collier P, Moravec CS, Phelan D, Donnellan E, Russell-Hallinan A, O’connor DP, Gallagher WM, Gallagher J, Mcdonald K, Ledwidge M, Baugh J, Das S, Watson CJ Circulation: Heart Failure 12(3) Published 1 Mar 2019

Transcriptome characterization of matched primary breast and brain metastatic tumors to detect novel actionable targets

[Journal Article] Varešlija D, Priedigkeit N, Fagan A, Purcell S, Cosgrove N, O’Halloran PJ, Ward E, Cocchiglia S, Hartmaier R, Castro CA, Zhu L, Tseng GC, Lucas PC, Puhalla SL, Brufsky AM, Hamilton RL, Mathew A, Leone JP, Basudan A, Hudson L, Dwyer R, Das S, O’Connor DP, Buckley PG, Farrell M, Hill ADK, Oesterreich S, Lee AV, Young LS Journal of the National Cancer Institute 111(4):388-398 Published 1 Jan 2019

2018

Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy

[Journal Article] Smeets D, Miller IS, O’Connor DP, Das S, Moran B, Boeckx B, Gaiser T, Betge J, Barat A, Klinger R, van Grieken NCT, Cremolini C, Prenen H, Mazzone M, Depreeuw J, Bacon O, Fender B, Brady J, Hennessy BT, McNamara DA, Kay E, Verheul HM, Maarten N, Gallagher WM, Murphy V, Prehn JHM, Koopman M, Punt CJA, Loupakis F, Ebert MPA, Ylstra B, Lambrechts D, Byrne AT Nature Communications 9(1) Published 1 Dec 2018

Epigenome-wide SRC-1-mediated gene silencing represses cellular differentiation in advanced breast cancer

[Journal Article] Ward E, Vareslija D, Charmsaz S, Fagan A, Browne AL, Cosgrove N, Cocchiglia S, Purcell SP, Hudson L, Das S, O’Connor D, O’Halloran PJ, Sims AH, Hill AD, Young LS Clinical Cancer Research 24(15):3692-3702 Published 1 Aug 2018

Loss of chromosome 18q11.2-q12.1 is predictive for survival in patients with metastatic colorectal cancer treated with bevacizumab

[Journal Article] Van Dijk E, Biesma HD, Cordes M, Smeets D, Neerincx M, Das S, Eijk PP, Murphy V, Barat A, Bacon O, Prehn JHM, Betge J, Gaiser T, Fender B, Meijer GA, McNamara DA, Klinger R, Koopman M, Ebert MPA, Kay EW, Hennessey BT, Verheul HMW, Gallagher WM, O’Connor DP, Punt CJA, Loupakis F, Lambrechts D, Byrne AT, Van Grieken NCT, Ylstra B Journal of Clinical Oncology 36(20):2052-2060 Published 10 Jul 2018

Dysregulated mitogen-activated protein kinase signalling as an oncogenic basis for clear cell sarcoma of the kidney

[Journal Article] Kenny C, McDonagh N, Lazaro A, O’Meara E, Klinger R, O’Connor D, Roche F, Hokamp K, O’Sullivan MJ Journal of Pathology 244(3):334-345 Published 1 Mar 2018

Mutant p53 as a therapeutic target for the treatment of triple-negative breast cancer: Preclinical investigation with the anti-p53 drug, PK11007

[Journal Article] Synnott NC, Bauer MR, Madden S, Murray A, Klinger R, O’Donovan N, O’Connor D, Gallagher WM, Crown J, Fersht AR, Duffy MJ Cancer Letters 414:99-106 Published 1 Feb 2018

BAG3 promotes tumour cell proliferation by regulating EGFR signal transduction pathways in triple negative breast cancer

[Journal Article] Shields S, Conroy E, O’Grady T, McGoldrick A, Connor K, Ward MP, Useckaite Z, Dempsey E, Reilly R, Fan Y, Chubb A, Matallanas DG, Kay EW, O’Connor D, McCann A, Gallagher WM, Coppinger JA Oncotarget 9(21):15673-15690 Published 1 Jan 2018

Assessing DNA methylation in cancer stem cells

[Chapter] Das S, Moran B, Perry AS Methods in Molecular Biology Pg. 157-178 Published 1 Jan 2018

2017

Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal

[Journal Article] Streubel G, Fitzpatrick DJ, Oliviero G, Scelfo A, Moran B, Das S, Munawar N, Watson A, Wynne K, Negri GL, Dillon ET, Jammula SG, Hokamp K, O’Connor DP, Pasini D, Cagney G, Bracken AP EMBO Journal 36(15):2216-2232 Published 1 Aug 2017

Therapeutic rationale to target highly expressed CDK7 conferring poor outcomes in triple-negative breast cancer

[Journal Article] Li B, Chonghaile TN, Fan Y, Madden SF, Klinger R, O’Connor AE, Walsh L, O’Hurley G, Udupi GM, Joseph J, Tarrant F, Conroy E, Gaber A, Chin SF, Bardwell HA, Provenzano E, Crown J, Dubois T, Linn S, Jirstrom K, Caldas C, O’Connor DP, Gallagher WM Cancer Research 77(14):3834-3845 Published 15 Jul 2017

Vitamin D receptor as a target for breast cancer therapy

[Journal Article] Murray A, Madden SF, Synnott NC, Klinger R, O’Connor D, O’Donovan N, Gallagher W, Crown J, Duffy MJ Endocrine-Related Cancer 24(4):181-195 Published 1 Apr 2017

The emerging role of nontraditional ubiquitination in oncogenic pathways

[Journal Article] Dwane L, Gallagher WM, Chonghaile TN, O’Connor DP Journal of Biological Chemistry 292(9):3543-3551 Published 3 Mar 2017

Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer

[Journal Article] Zuurbier L, Rahman A, Cordes M, Scheick J, Wong TJ, Rustenburg F, Joseph JC, Dynoodt P, Casey R, Drillenburg P, Gerhards M, Barat A, Klinger R, Fender B, O’Connor DP, Betge J, Ebert MP, Gaiser T, Prehn JHM, Griffioen AW, van Grieken NCT, Ylstra B, Byrne AT, van der Flier LG, Gallagher WM, Postel R Oncotarget 8(26):42949-42961 Published 1 Jan 2017

Assessment of concordance between fresh-frozen and formalin-fixed paraffin embedded tumor DNA methylation using a targeted sequencing approach

[Journal Article] Moran B, Das S, Smeets D, Peutman G, Klinger R, Fender B, Connor K, Ebert M, Gaiser T, Prehn JHM, Bacon O, Kay E, Hennessy B, Murphy V, Ylstra B, Lambrechts D, Byrne AT, Gallagher WM, O’Connor DP Oncotarget 8(29):48126-48137 Published 1 Jan 2017

Mutant p53: a novel target for the treatment of patients with triple-negative breast cancer?

[Journal Article] Synnott NC, Murray A, McGowan PM, Kiely M, Kiely PA, O’Donovan N, O’Connor DP, Gallagher WM, Crown J, Duffy MJ International Journal of Cancer 140(1):234-246 Published 1 Jan 2017

Postmortem examination of an aggressive case of medullary thyroid carcinoma characterized by catastrophic genomic abnormalities

[Journal Article] Das S, Kelly D, Moran B, Han K, Mulligan N, Barrett C, Buckley PG, McMahon P, McCaffrey J, Van Essen HF, Connor K, Lambrechts D, Ylstra B, Gallagher WM, O’Connor DP, Kelly CM JCO Precision Oncology 2017(1):1-7 Published 1 Jan 2017

2016

Copy number alterations as predictive biomarkers for response to bevacizumab in metastatic colorectal cancer

[Journal Article] van Grieken NC, Cordes M, Verheul HM, Neerincx M, Punt C, Koopman M, Meijer GA, Murphy V, Barat A, Betge J, Ebert M, Gaiser T, Fender B, Klinger R, Das S, Smeets D, O’Connor D, Lambrechts D, Byrne AT, Ylstra B Annals of Oncology 27:vi15 Published 1 Oct 2016

De novo post-diagnosis statin use, breast cancer-specific and overall mortality in women with stage I-III breast cancer

[Journal Article] Smith A, Murphy L, Sharp L, O’Connor D, Gallagher WM, Bennett K, Barron TI British Journal of Cancer 115(5):592-598 Published 23 Aug 2016

Biosimilars: Extrapolation for oncology

[Journal Article] Curigliano G, O’Connor DP, Rosenberg JA, Jacobs I Critical Reviews in Oncology/Hematology 104:131-137 Published 1 Aug 2016

Diagnostic and Therapeutic Implications of Histone Epigenetic Modulators in Breast Cancer

[Journal Article] Walsh L, Gallagher WM, Oconnor DP, Ní Chonghaile T Expert Review of Molecular Diagnostics 16(5):541-551 Published 3 May 2016

Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer

[Journal Article] Michaut M, Chin SF, Majewski I, Severson TM, Bismeijer T, De Koning L, Peeters JK, Schouten PC, Rueda OM, Bosma AJ, Tarrant F, Fan Y, He B, Xue Z, Mittempergher L, Kluin RJC, Heijmans J, Snel M, Pereira B, Schlicker A, Provenzano E, Ali HR, Gaber A, O’Hurley G, Lehn S, Muris JJF, Wesseling J, Kay E, Sammut SJ, Bardwell HA, Barbet AS, Bard F, Lecerf C, O’Connor DP, Vis DJ, Benes CH, McDermott U, Garnett MJ, Simon IM, Jirström K, Dubois T, Linn SC, Gallagher WM, Wessels LFA, Caldas C, Bernards R Scientific Reports 6 Published 5 Jan 2016

RE: RNA disruption assay as a biomarker of pathological complete response in Neoadjuvant Trastuzumab-treated human epidermal growth factor receptor 2-positive breast cancer

[Journal Article] Toomey S, Eustace AJ, Pritzker LB, Pritzker KPH, Fay J, O’Grady A, Cummins R, Grogan L, Kennedy J, O’Connor D, Young L, Kay EW, O’Donovan N, Gallagher WM, Kalachand R, Crown J, Hennessy BT Journal of the National Cancer Institute 108(8) Published 1 Jan 2016

Assessment of Significance of Novel Proteins in Breast Cancer Using Tissue Microarray Technology

[Chapter] Mulrane L, Gallagher W, O’Connor DP Mammary Gland Development Methods and Protocols Published 2016

2015

Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and insulin resistance despite obesity

[Journal Article] Finucane OM, Lyons CL, Murphy AM, Reynolds CM, Klinger R, Healy NP, Cooke AA, Coll RC, Mcallan L, Nilaweera KN, O’Reilly ME, Tierney AC, Morine MJ, Alcala-Diaz JF, Lopez-Miranda J, O’Connor DP, O’Neill LA, Mcgillicuddy FC, Roche HM Diabetes 64(6):2116-2128 Published 1 Jun 2015

FKBPL: A marker of good prognosis in breast cancer

[Journal Article] Nelson L, McKeen HD, Marshall A, Mulrane L, Starczynski J, Storr SJ, Lanigan F, Byrne C, Arthur K, Hegarty S, Ali AA, Furlong F, McCarthy HO, Ellis IO, Green AR, Rakha E, Young L, Kunkler I, Thomas J, Jack W, Cameron D, Jirström K, Yakkundi A, McClements L, Martin SG, Gallagher WM, Dunn J, Bartlett J, O’Connor D, Robson T Oncotarget 6(14):12209-12223 Published 1 Jan 2015

Differential DNA methylation profiles of coding and non-coding genes define hippocampal sclerosis in human temporal lobe epilepsy

[Journal Article] Miller-Delaney SFC, Bryan K, Das S, McKiernan RC, Bray IM, Reynolds JP, Gwinn R, Stallings RL, Henshall DC Brain 138(3):616-631 Published 1 Jan 2015

2014

A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer

[Journal Article] Mulrane L, Gallagher WM, O’Connor DP Breast Cancer Research 16(1) Published 18 Nov 2014

Dynamic and influential interaction of cancer cells with normal epithelial cells in 3D culture

[Journal Article] Ivers LP, Cummings B, Owolabi F, Welzel K, Klinger R, Saitoh S, O’Connor D, Fujita Y, Scholz D, Itasaki N Cancer Cell International 14(1) Published 30 Oct 2014

Peroxiredoxin-1 protects estrogen receptor α from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer

[Journal Article] O’Leary PC, Terrile M, Bajor M, Gaj P, Hennessy BT, Mills GB, Zagozdzon A, O’Connor DP, Brennan DJ, Connor K, Li J, Gonzalez-Angulo AM, Sun HD, Pu JX, Pontén F, Uhlén M, Jirström K, Nowis DA, Crown JP, Zagozdzon R, Gallagher WM Breast Cancer Research 16(4) Published 10 Jul 2014

P53 as a target for the treatment of cancer

[Journal Article] Duffy MJ, Synnott NC, McGowan PM, Crown J, O’Connor D, Gallagher WM Cancer Treatment Reviews 40(10):1153-1160 Published 1 Jan 2014

MicroRNAs: A new class of breast cancer biomarkers

[Journal Article] Mulrane L, Klinger R, McGee SF, Gallagher WM, O’Connor DP Expert Review of Molecular Diagnostics 14(3):347-363 Published 1 Jan 2014

2013

miRNA dysregulation in breast cancer

[Journal Article] Mulrane L, McGee SF, Gallagher WM, O’Connor DP Cancer Research 73(22):6554-6562 Published 15 Nov 2013

Investigating gene promoter methylation in a mouse model of status epilepticus

[Chapter] Miller-Delaney SF, Das S, Stallings RL, Henshall DC Tiling Arrays Methods and Protocols Published by Humana Press Published 5 Sep 2013

Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAs

[Journal Article] Das S, Bryan K, Buckley PG, Piskareva O, Bray IM, Foley N, Ryan J, Lynch J, Creevey L, Fay J, Prenter S, Koster J, Van Sluis P, Versteeg R, Eggert A, Schulte JH, Schramm A, Mestdagh P, Vandesompele J, Speleman F, Stallings RL Oncogene 32(24):2927-2936 Published 13 Jun 2013

Identification of transcription factors associated with castration-resistance: Is the serum responsive factor a potential therapeutic target?

[Journal Article] Prencipe M, Madden SF, O’Neill A, O’Hurley G, Culhane A, O’Connor D, Klocker H, Kay EW, Gallagher WM, Watson WR Prostate 73(7):743-753 Published 1 May 2013

Ghrelin concentrations in maternal and cord blood of Type 1 diabetic and non-diabetic pregnancies at term

[Journal Article] Hehir MP, Laursen H, Higgins MF, Brennan DJ, O’Connor DP, McAuliffe FM Endocrine 43(1):233-235 Published 1 Feb 2013

2012

miR-187 is an independent prognostic factor in breast cancer and confers increased invasive potential in vitro

[Journal Article] Mulrane L, Madden SF, Brennan DJ, Gremel G, McGee SF, McNally S, Martin F, Crown JP, Jirström K, Higgins DG, Gallagher WM, O’Connor DP Clinical Cancer Research 18(24):6702-6713 Published 15 Dec 2012

Maternal and fetal cocaine- and amphetamine-regulated transcript in diabetic and non-diabetic pregnancy

[Journal Article] Hehir MP, Laursen H, Higgins MF, Brennan DJ, O’Connor DP, McAuliffe FM Gynecological Endocrinology 28(9):682-685 Published 1 Sep 2012

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis

[Journal Article] Jamieson T, Clarke M, Steele CW, Samuel MS, Neumann J, Jung A, Huels D, Olson MF, Das S, Nibbs RJB, Sansom OJ Journal of Clinical Investigation 122(9):3127-3144 Published 4 Sep 2012

Molecular correlates and prognostic significance of SATB1 expression in colorectal cancer

[Journal Article] Nodin B, Johannesson H, Wangefjord S, O’Connor DP, Lindquist KE, Uhlén M, Jirström K, Eberhard J Diagnostic Pathology 7(1) Published 30 Aug 2012

The cocaine-and amphetamine-regulated transcript mediates ligand-independent activation of ERα, and is an independent prognostic factor in node-negative breast cancer

[Journal Article] Brennan DJ, O’connor DP, Laursen H, Mcgee SF, Mccarthy S, Zagozdzon R, Rexhepaj E, Culhane AC, Martin FM, Duffy MJ, Landberg G, Ryden L, Hewitt SM, Kuhar MJ, Bernards R, Millikan RC, Crown JP, Jirström K, Gallagher WM Oncogene 31(30):3483-3494 Published 6 Jul 2012

Differential DNA methylation patterns define status epilepticus and epileptic tolerance

[Journal Article] Miller-Delaney SFC, Das S, Sano T, Jimenez-Mateos EM, Bryan K, Buckley PG, Stallings RL, Henshall DC Journal of Neuroscience 32(5):1577-1588 Published 1 Feb 2012

2011

Identification of a myometrial molecular profile for dystocic labor

[Journal Article] Brennan DJ, McGee SF, Rexhepaj E, O’Connor DP, Robson M, O’Herlihy C BMC Pregnancy and Childbirth 11 Published 16 Oct 2011

MicroRNA and DNA methylation alterations mediating retinoic acid induced neuroblastoma cell differentiation

[Journal Article] Stallings RL, Foley NH, Bray IM, Das S, Buckley PG Seminars in Cancer Biology 21(4):283-290 Published 1 Oct 2011

SATB2 in combination with cytokeratin 20 identifies over 95% of all colorectal carcinomas

[Journal Article] Magnusson K, De Wit M, Brennan DJ, Johnson LB, McGee SF, Lundberg E, Naicker K, Klinger R, Kampf C, Asplund A, Wester K, Gry M, Bjartell A, Gallagher WM, Rexhepaj E, Kilpinen S, Kallioniemi OP, Belt E, Goos J, Meijer G, Birgisson H, Glimelius B, Borrebaeck CAK, Navani S, Uhlén M, O’Connor DP, Jirström K, Pontén F American Journal of Surgical Pathology 35(7):937-948 Published 1 Jul 2011

MicroRNAs 10a and 10b are potent inducers of neuroblastoma cell differentiation through targeting of nuclear receptor corepressor 2

[Journal Article] Foley NH, Bray I, Watters KM, Das S, Bryan K, Bernas T, Prehn JHM, Stallings RL Cell Death and Differentiation 18(7):1089-1098 Published 1 Jul 2011

Co-localization of the oncogenic transcription factor MYCN and the DNA methyl binding protein MeCP2 at genomic sites in neuroblastoma

[Journal Article] Murphy DM, Buckley PG, Das S, Watters KM, Bryan K, Stallings RL PLoS ONE 6(6) Published 27 Jun 2011

Genome-wide DNA methylation analysis of neuroblastic tumors reveals clinically relevant epigenetic events and large-scale epigenomic alterations localized to telomeric regions

[Journal Article] Buckley PG, Das S, Bryan K, Watters KM, Alcock L, Koster J, Versteeg R, Stallings RL International Journal of Cancer 128(10):2296-2305 Published 1 May 2011

Tumor-specific HMG-CoA reductase expression in primary premenopausal breast cancer predicts response to tamoxifen

[Journal Article] Brennan DJ, Laursen H, O’Connor DP, Borgquist S, Uhlen M, Gallagher WM, Pontén F, Millikan RC, Rydén L, Jirström K Breast Cancer Research 13(1) Published 31 Jan 2011

Characterisation and manipulation of docetaxel resistant prostate cancer cell lines.

[Journal Article] O’Neill AJ, Prencipe M, Dowling C, Fan Y, Mulrane L, Gallagher WM, O’Connor D, O’Connor R, Devery A, Corcoran C, Rani S, O’Driscoll L, Fitzpatrick JM, Watson RWG Molecular cancer 10:126 Published 1 Jan 2011

2010

Validation of cytoplasmic-to-nuclear ratio of survivin as an indicator of improved prognosis in breast cancer

[Journal Article] Rexhepaj E, Jirstrom K, O’Connor DP, O’Brien SL, Landberg G, Duffy MJ, Brennan DJ, Gallagher WM BMC Cancer 10 Published 23 Nov 2010

MicroRNA mediates DNA demethylation events triggered by retinoic acid during neuroblastoma cell differentiation

[Journal Article] Das S, Foley N, Bryan K, Watters KM, Bray I, Murphy DM, Buckley PG, Stallings RL Cancer Research 70(20):7874-7881 Published 15 Oct 2010

Antibody-based proteomics: Fast-tracking molecular diagnostics in oncology

[Journal Article] Brennan DJ, O’Connor DP, Rexhepaj E, Ponten F, Gallagher WM Nature Reviews Cancer 10(9):605-617 Published 1 Sep 2010

Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer

[Journal Article] Ehlén A, Brennan DJ, Nodin B, O’Connor DP, Eberhard J, Alvarado-Kristensson M, Jeffrey IB, Manjer J, Brändstedt J, Uhlén M, Pontén F, Jirström K Journal of Translational Medicine 8 Published 20 Aug 2010

Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer

[Journal Article] Brennan DJ, Brändstedt J, Rexhepaj E, Foley M, Pontén F, Uhlén M, Gallagher WM, O’Connor DP, O’Herlihy C, Jirstrom K BMC Cancer 10 Published 1 Apr 2010

Erratum: Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro (British Journal of Cancer (2010) 102 (456) DOI: 10.1038/sj.bjc.6605533))

[Journal Article] Prencipe M, Fitzpatrick P, Gorman S, Tosetto M, Klinger R, Furlong F, Harrison M, O’Connor D, Roninson IB, O’Sullivan J, McCann A British Journal of Cancer 102(2):456 Published 1 Jan 2010

2009

Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro

[Journal Article] Prencipe M, Fitzpatrick P, Gorman S, Mosetto M, Klinger R, Furlong F, Harrison M, O’Connor D, Roninson IB, O’Sullivan J, McCann A British Journal of Cancer 101(11):1900-1908 Published 1 Dec 2009

Global MYCN transcription factor binding analysis in neuroblastoma reveals association with distinct E-box motifs and regions of DNA hypermethylation

[Journal Article] Murphy DM, Buckley PG, Bryan K, Das S, Alcock L, Foley NH, Prenter S, Bray I, Watters KM, Higgins D, Stallings RL PLoS ONE 4(12) Published 1 Dec 2009

Cancer proteomics – An evolving battlefield: Conference on cancer proteomics 2009: Mechanistic insights, technological advances & molecular medicine

[Journal Article] Collins BC, Lau TYK, O’Connor DP, Hondermarck H EMBO Reports 10(11):1202-1205 Published 1 Oct 2009

The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer

[Journal Article] Brennan DJ, Ek S, Doyle E, Drew T, Foley M, Flannelly G, O’Connor DP, Gallagher WM, Kilpinen S, Kallioniemi OP, Jirstrom K, O’Herlihy C, Borrebaeck CAK European Journal of Cancer 45(8):1510-1517 Published 1 May 2009

2008

Altered cytoplasmic-to-nuclear ratio of survivin is a prognostic indicator in breast cancer

[Journal Article] Brennan DJ, Rexhepaj E, O’Brien SL, McSherry E, O’Connor DP, Fagan AI, Culhane AC, Higgins DG, Jirstrom K, Millikan RC, Landberg G, Duffy MJ, Hewitt SM, Gallagher WM Clinical Cancer Research 14(9):2681-2689 Published 1 May 2008

2007

Breast cancer proteomics: Clinical perspectives

[Journal Article] Lau TYK, O’Connor DP, Brennan DJ, Duffy MJ, Pennington SR, Gallagher WM Expert Opinion on Biological Therapy 7(2):209-219 Published 1 Feb 2007

Molecular links between mammary gland development and breast cancer

[Journal Article] Lanigan F, O’Connor D, Martin F, Gallagher WM Cellular and Molecular Life Sciences 64(24):3161-3184 Published 1 Jan 2007

2006

Molecular basis of cell-biomaterial interaction: Insights gained from transcriptomic and proteomic studies

[Journal Article] Gallagher WM, Lynch I, Allen LT, Miller I, Penney SC, O’Connor DP, Pennington S, Keenan AK, Dawson KA Biomaterials 27(35):5871-5882 Published 1 Dec 2006

Proteomic analysis of factors released from p21-overexpressing tumour cells

[Journal Article] Currid CA, O’Connor DP, Chang BD, Gebus C, Harris N, Dawson KA, Dunn MJ, Pennington SR, Roninson IB, Gallagher WM Proteomics 6(13):3739-3753 Published 1 Jul 2006

Surface-induced changes in protein adsorption and implications for cellular phenotypic responses to surface interaction

[Journal Article] Allen LT, Tosetto M, Miller IS, O’Connor DP, Penney SC, Lynch I, Keenan AK, Pennington SR, Dawson KA, Gallagher WM Biomaterials 27(16):3096-3108 Published 1 Jun 2006

DNA-damage-responsive acetylation of pRb regulates binding to E2F-1

[Journal Article] Markham D, Munro S, Soloway J, O’Connor DP, La Thangue NB EMBO Reports 7(2):192-198 Published 1 Feb 2006

2004

A new effector pathway links ATM kinase with the DNA damage response

[Journal Article] Demonacos C, Krstic-Demonacos M, Smith L, Xu D, O’Connor DP, Jansson M, La Thangue NB Nature Cell Biology 6(10):968-976 Published 1 Oct 2004

2001

Altered p53 expression in benign and malignant skin lesions from renal transplant recipients and immunocompetent patients with skin cancer: Correlation with human papillomaviruses?

[Journal Article] O’Connor DP, Kay EW, Leader M, Murphy GM, Atkins GJ, Mabruk MJEMF Diagnostic Molecular Pathology 10(3):190-199 Published 12 Sep 2001

p53 codon 72 polymorphism and human papillomavirus associated skin cancer

[Journal Article] O’Connor DP, Kay EW, Leader M, Atkins GJ, Murphy GM, Mabruk MJEMF Journal of Clinical Pathology 54(7):539-542 Published 24 Jul 2001

A high degree of chromosomal instability at 13q14 in cutaneous squamous cell carcinomas: Indication for a role of a tumour suppressor gene other than Rb

[Journal Article] O’Connor DP, Kay EW, Leader M, Murphy GM, Atkins GJ, Mabruk MJEMF Journal of Clinical Pathology – Molecular Pathology 54(3):165-169 Published 26 Jun 2001

1997

The role of human papilloma virus in skin cancer – Current status

[Journal Article] McKenna DB, O’Connor D, Kay E, Leader M, Murphy GM Journal of the European Academy of Dermatology and Venereology 9(2):103-110 Published 1 Jan 1997